2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1874):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-18684
    SIBA
    		99.64%
    SIBA (5'-Isobutylthioadenosine) is a transmethylation inhibitor (SAH (HY-19528) analogue), with potent anti-proliferative activity. SIBA reversibly inhibits the production of HSV-1 by blocking methylation, specifically by blocking the 5' end-capping of viral mRNA. SIBA also inhibits the growth of tumour cells in vitro and metastatic spread in vivo. SIBA can be used in cancer, HSV-1 infection and anti-malaria studies.
    SIBA
  • HY-138597
    5'-O-TBDMS-dT
    		99.43%
    5'-O-TBDMS-dT is a nucleoside with protective and modification effects.
    5'-O-TBDMS-dT
  • HY-122524S
    7-Methylguanosine-d3
    		98.54%
    7-Methylguanosine-d3 is the deuterium labeled 7-Methylguanosine. 7-Methylguanosine is a novel cNIIIB nucleotidase inhibitor with IC50 value of 87.8 ± 7.5 μM.
    7-Methylguanosine-d<sub>3</sub>
  • HY-W009538
    5'-Deoxy-5-fluorocytidine
    		99.91%
    5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer.
    5'-Deoxy-5-fluorocytidine
  • HY-W006102
    Bz-rA Phosphoramidite
    		99.03%
    Bz-rA Phosphoramidite is used for ribonucleotides modification.
    Bz-rA Phosphoramidite
  • HY-16445
    Sapacitabine
    		Chemical 98.13%
    Sapacitabine is an orally available nucleoside analog proagent that is structurally related to cytarabine.
    Sapacitabine
  • HY-B1449S1
    Uridine-13C
    		≥99.0%
    Uridine-13C is the 13C labeled Uridine.
    Uridine-<sup>13</sup>C
  • HY-W102981
    4,10-Dioxatri cyclo[5.2. 1.02.6]dec-8-ene-3,5-dione
    4,10-Dioxatri cyclo[5.2. 1.02.6]dec-8-ene-3,5-dione is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    4,10-Dioxatri cyclo[5.2. 1.02.6]dec-8-ene-3,5-dione
  • HY-131818
    5'-Amino-5'-deoxyadenosine
    5'-Amino-5'-deoxyadenosine (NH2dAdo; Nsc 238990) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5'-Amino-5'-deoxyadenosine
  • HY-106014
    Tezacitabine
    		99.97%
    Tezacitabine is a cytostatic and cytotoxic antimetabolite and a nucleoside analogue. Tezacitabine irreversibly inhibits the ribonucleotide reductase and interferes with DNA replication and repair. Tezacitabine effectively induces cells apoptotic. Tezacitabine has the potential for leukemias and solid tumors (carcinomas) treatment.
    Tezacitabine
  • HY-111648
    6-O-Methyl Guanosine
    		99.65%
    6-O-Methyl Guanosine is a modified nucleoside. 6-O-Methyl Guanosine (6-methylguanosine) inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line.
    6-O-Methyl Guanosine
  • HY-W406070
    2'-O,4'-C-Methyleneguanosine
    		99.22%
    2′-O,4′-C-Methyleneguanosine (LNA-G) is a reverse guanine analog, where LNA (locked nucleic acid) is a nucleic acid analog. LNA modification can be widely used in various fields, such as effective binding affinity with complementary sequences and stronger nuclease resistance than natural nucleotides, providing great potential for application in disease diagnosis and research. LNA-G can also be incorporated into the DNA chain by KOD DNA polymerase.
    2'-O,4'-C-Methyleneguanosine
  • HY-124143
    Isoguanine
    		99.64%
    Isoguanine is a purine base that is an isomer of Guanine. A building block in organic synthesis.
    Isoguanine
  • HY-W091784
    3'-O-Methylguanosine
    		98.66%
    3'-O-Methylguanosine is a methylated nucleoside analogs and a RNA chain terminator. 3'-O-methylguanosine can inhibit early virus-specific RNA synthesis.
    3'-O-Methylguanosine
  • HY-W002272
    Isocytosine
    		99.71%
    Isocytosine is a non-natural nucleobase and an isomer of cytosine. It is used in combination with Isoguanine in studies of unnatural nucleic acid analogues of the normal base pairs in DNA and used as a nucleobase of hachimoji RNA.
    Isocytosine
  • HY-106934A
    Peldesine dihydrochloride
    		99.28%
    Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine dihydrochloride is also a T-cell proliferation inhibitor with an IC50 of 800 nM. Peldesine dihydrochloride has the potential for cutaneous T-cell lymphoma, psoriasis and HIV infection research.
    Peldesine dihydrochloride
  • HY-154510
    2’-Deoxy-N4-methylcytidine
    		98.04%
    2’-Deoxy-N4-methylcytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Deoxy-N4-methylcytidine
  • HY-W115186
    DMT-2'-OMe-Bz-C
    		99.11%
    DMT-2'-OMe-Bz-C is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities.
    DMT-2'-OMe-Bz-C
  • HY-101970
    Deoxypseudouridine
    		Chemical 98.25%
    Deoxypseudouridine is a nucleoside analog.
    Deoxypseudouridine
  • HY-148505
    5'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite)
    		99.17%
    5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite blongs to modified antisense oligonucleotide. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite allows the formation of a specific conformation of the furanose ring of the oligonucleotide through the introduction of a cEt modification, enhancing the ability to hybridize to complementary RNA. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is mainly used in the research of regulation of gene expression related to metabolic diseases, cardiovascular diseases, cancers and the development of antisense compounds.
    5'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite)