2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1797):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-138597
    5'-O-TBDMS-dT
    		99.43%
    5'-O-TBDMS-dT is a nucleoside with protective and modification effects.
    5'-O-TBDMS-dT
  • HY-B0228S
    Adenosine-d
    		Chemical 99.72%
    Adenosine-d is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
    Adenosine-d
  • HY-131818
    5'-Amino-5'-deoxyadenosine
    5'-Amino-5'-deoxyadenosine (NH2dAdo; Nsc 238990) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5'-Amino-5'-deoxyadenosine
  • HY-111648
    6-O-Methyl Guanosine
    		99.65%
    6-O-Methyl Guanosine is a modified nucleoside. 6-O-Methyl Guanosine (6-methylguanosine) inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line.
    6-O-Methyl Guanosine
  • HY-W406070
    2'-O,4'-C-Methyleneguanosine
    		99.22%
    2′-O,4′-C-Methyleneguanosine (LNA-G) is a reverse guanine analogue, where LNA (locked nucleic acid) is a nucleic acid analogue. LNA modification can be used in a variety of applications such as effective binding affinity to complementary sequences and greater nuclease resistance than natural nucleotides, offering great potential for applications in disease diagnosis and research. LNA-G is also available via KOD DNA polymerase, which allows the integration of LNA-G nucleotides into the DNA strand.
    2'-O,4'-C-Methyleneguanosine
  • HY-124143
    Isoguanine
    		99.64%
    Isoguanine is a purine base that is an isomer of Guanine. A building block in organic synthesis.
    Isoguanine
  • HY-W091784
    3'-O-Methylguanosine
    		98.66%
    3'-O-Methylguanosine is a methylated nucleoside analogs and a RNA chain terminator. 3'-O-methylguanosine can inhibit early virus-specific RNA synthesis.
    3'-O-Methylguanosine
  • HY-W002272
    Isocytosine
    		99.71%
    Isocytosine is a non-natural nucleobase and an isomer of cytosine. It is used in combination with Isoguanine in studies of unnatural nucleic acid analogues of the normal base pairs in DNA and used as a nucleobase of hachimoji RNA.
    Isocytosine
  • HY-102071
    KIN59
    		Inhibitor ≥99.0%
    KIN59 (5’-O-Tritylinosine) is a potent thymidine phosphorylase allosteric inhibitor. KIN59 inhibits FGF2-stimulated cell growth. KIN59 inhibits the expression of p-FGFR1, P-Akt in FGF2 (10 ng/mL) stimulated cells. KIN59 shows anti-tumor activity.
    KIN59
  • HY-106934A
    Peldesine dihydrochloride
    		99.63%
    Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine dihydrochloride is also a T-cell proliferation inhibitor with an IC50 of 800 nM. Peldesine dihydrochloride has the potential for cutaneous T-cell lymphoma, psoriasis and HIV infection research.
    Peldesine dihydrochloride
  • HY-16445
    Sapacitabine
    		Chemical 98.13%
    Sapacitabine is an orally available nucleoside analog proagent that is structurally related to cytarabine.
    Sapacitabine
  • HY-B1449S1
    Uridine-13C
    Uridine-13C is the 13C labeled Uridine.
    Uridine-<sup>13</sup>C
  • HY-W115186
    DMT-2'-OMe-Bz-C
    		99.11%
    DMT-2'-OMe-Bz-C is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities.
    DMT-2'-OMe-Bz-C
  • HY-W102981
    4,10-Dioxatri cyclo[5.2. 1.02.6]dec-8-ene-3,5-dione
    4,10-Dioxatri cyclo[5.2. 1.02.6]dec-8-ene-3,5-dione is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    4,10-Dioxatri cyclo[5.2. 1.02.6]dec-8-ene-3,5-dione
  • HY-101970
    Deoxypseudouridine
    		Chemical 98.61%
    Deoxypseudouridine is a nucleoside analog.
    Deoxypseudouridine
  • HY-148505
    5'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite)
    		99.17%
    5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite blongs to modified antisense oligonucleotide. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite allows the formation of a specific conformation of the furanose ring of the oligonucleotide through the introduction of a cEt modification, enhancing the ability to hybridize to complementary RNA. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is mainly used in the research of regulation of gene expression related to metabolic diseases, cardiovascular diseases, cancers and the development of antisense compounds.
    5'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite)
  • HY-B0158S7
    Cytidine-13C9
    		Chemical
    Cytidine-13C9 (Cytosine β-D-riboside-13C9; Cytosine-1-β-D-ribofuranoside-13C9) is 13C labeled Cytidine (HY-B0158). Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function.
    Cytidine-<sup>13</sup>C<sub>9</sub>
  • HY-W244398
    2-Thiocytidine
    		99.20%
    2-Thiocytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2-Thiocytidine
  • HY-106014
    Tezacitabine
    		99.97%
    Tezacitabine is a cytostatic and cytotoxic antimetabolite and a nucleoside analogue. Tezacitabine irreversibly inhibits the ribonucleotide reductase and interferes with DNA replication and repair. Tezacitabine effectively induces cells apoptotic. Tezacitabine has the potential for leukemias and solid tumors (carcinomas) treatment.
    Tezacitabine
  • HY-W016041
    2-Amino-2'-deoxyadenosine
    		99.62%
    2-Amino-2'-deoxyadenosine is a deoxyribonucleoside used for the oligonucleotide synthesis.
    2-Amino-2'-deoxyadenosine